Quetiapine

Quetiapine (INN), known in the United States by the brand name Seroquel^®, is one of the atypical antipsychotics. Quetiapine (kwe-TYE-a-peen) has FDA and international approvals for the treatment of schizophrenia and acute mania in bipolar disorder. It is used "off-label" to treat other disorders, such as post-traumatic stress disorder, and as a sedative for those with sleep disorders.

Chemistry

Quetiapine is 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine, C₂₁H₂₅N₃O₂S.

How it works

Quetiapine is a dopamine, specifically D1 and D₂ dopamine, inhibitor or antagonist. It also somewhat inhibits functioning of serotonin receptors, but in clinical tests it has been found that the human body is very adaptive to the serotonin blocking reaction, thus it can be used together with SSRI medication.

Side effects

Quetiapine is believed to be less likely to cause tardive dyskinesia than typical antipsychotics. However, as with other antipsychotics, there is evidence implying that quetiapine may cause tardive dyskinesia. [1] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11579018&dopt=Abstract) [2] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10327920&dopt=Abstract)

Studies conducted on beagles have resulted in the formation of cataracts, however, there has been no report describing this effect within humans. Common side effects include: agitation, memory problems, sedation, and an upset stomach. More information on side effects can be found at NIH's profile of the medication (http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203124.html). Seroquel will put the patient into a drowsy state, and will help the patient fall asleep.

External links

• Seroquel (http://www.seroquel.com/)
• Quetiapine Fumarate (http://www.rxlist.com/cgi/generic2/quetiap.htm) - from RxList

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SEE BNF FOR FURTHER NOTES ON SEROQUEL. CHECK http://www.bnf.org/bnf