GRK3

In 2003, a group of American and Canadian researchers published a paper that used gene linkage techniques to identify a mutation in the GRK3 gene as a possible cause of up to 10% of cases of bipolar disorder. This gene is associated with a kinase enzyme called G protein receptor kinase 3, which appears to be involved in dopamine metabolism, and may provide a possible target for new drugs for bipolar disorder.

References

T B Barrett, R L Hauger, J L Kennedy, A D Sadovnick, R A Remick, P E Keck, S L McElroy, M Alexander, S H Shaw, and J R Kelsoe, "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder", in Molecular Psychiatry, 2003, Volume 8, Number 5, Pages 546-557.

External links

Online version of the paper in Molecular Psychiatry (http://www.nature.com/cgi-taf/DynaPage.taf?file=/mp/journal/v8/n5/abs/4001268a.html&dynoptions=doi1056040331)
PubMed abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12808434&dopt=Abstract)
Report from sciencedaily.com (http://www.sciencedaily.com/releases/2003/06/030617080403.htm)

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